May 13, 2019· INDICATIONS. Collagenase Santyl® Ointment is indicated for debriding chronic dermal ulcers 2,3,4,5,6,8,9,10,11,12,13,14,15,16,17,18 and severely burned areas. 3,4,5,7,16,19,20,21 DOSAGE AND ADMINISTRATION. Collagenase Santyl® Ointment should be applied once daily (or more frequently if the dressing becomes soiled, as from incontinence).When clinically indicated, …